Pro 1 Pico vs PicoSure® Pro

How does Pro 1 Pico compare with PicoSure Pro?

Pro 1 Pico is built around native 1064 nm Nd:YAG with integrated 532 nm, while PicoSure Pro is built around a native 755 nm Alexandrite source. Pro 1 Pico adds twin pulse delivery for Fitzpatrick IV–VI protocols and picosecond, quasi-nanosecond PicoFusion™ and Long Pulse YAG modes, bringing tattoo, PMU and skin-quality services into one platform.

The right laser gives your clinic room to grow. From unwanted tattoos and permanent makeup to pigmentation and skin texture, Pro 1 Pico brings together the wavelengths, delivery modes and handpieces to build a versatile treatment menu.

Native 1064 nm. Twin pulse delivery for Fitzpatrick IV–VI. Picosecond, quasi-nanosecond and Long Pulse YAG modes.

Pro 1 Pico puts these capabilities in one platform, backed by manufacturer-direct training and clinical support. If you are considering PicoSure Pro, here are the differences that make Pro 1 Pico worth a closer look.

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Why does 755 nm versus 1064 nm matter?

PicoSure Pro is built around a native 755 nm Alexandrite source.^[1] Pro 1 Pico is built around native 1064 nm Nd:YAG.

755 nm has greater affinity for melanin than 1064 nm. The lower epidermal melanin absorption and generally deeper penetration of 1064 nm are relevant when planning pigment-focused services for a diverse patient population.^[3]

Pro 1 Pico also provides 532 nm through integrated frequency doubling. PicoSure Pro offers 532 and 1064 nm through optional delivery systems that convert its 755 nm output. With Pro 1 Pico, native 1064 nm and integrated 532 nm form the core wavelength configuration.^[2]

How do the platforms compare feature by feature?

Accessory inclusions vary by package. The 30-million figure is a platform pulse allowance; individual optic replacement terms are separate.

Which platform fits the patients you treat?

PicoSure Pro offers picosecond treatment for tattoos, pigment and skin revitalization.^[2] Pro 1 Pico combines that treatment focus with three delivery modes, a native 1064 nm foundation and a choice of single or twin pulse delivery. Here is what that configuration can bring to your clinic.

Do you treat Fitzpatrick IV–VI?

Make native 1064 nm and twin pulse delivery part of your equipment decision. Pro 1 Pico gives you this wavelength from its native Nd:YAG source, with twin pulse options for its Fitzpatrick IV–VI protocols.

There is clinical interest in dividing delivery into two pulses. In a 2019 split-face study of 12 women with Fitzpatrick III–IV melasma, a nanosecond 1064 nm twin pulse mode achieved similar pigment improvement to single pulse, with less reported pain and immediate redness.^[6] This supports interest in pulse-delivery choices; it does not establish comparative safety for Pro 1 Pico or Fitzpatrick V–VI.

For your clinic: a native 1064 nm platform, a choice of pulse delivery and training built around your patient mix. See these features demonstrated before you choose your equipment.

Do you treat melasma?

Bring 1064 nm picosecond delivery and Long Pulse YAG into the same equipment purchase. Pro 1 Pico gives your team pigment-focused and thermal delivery options for a condition that requires an individualized, ongoing management plan.

A 2023 split-face study comparing 1064 nm picosecond treatment with nanosecond twin pulse treatment found that both improved melasma severity in Fitzpatrick III–IV participants, with no statistically significant difference in pigment improvement between treatments.^[7] A 2026 randomized split-face trial also found improvement with both picosecond and nanosecond 1064 nm treatment, without a significant difference in severity scores.^[10]

The buying advantage is flexibility: choose a platform that brings several delivery options together, with training to help your team connect the equipment to its melasma service.

Does your melasma service also assess redness and vascular changes?

Melasma can include changes in the dermal environment alongside visible pigment. A study of skin samples from 50 women found increased blood-vessel size and density in melasma lesions.^[8] Those findings give clinicians a reason to assess vascular changes as part of the overall presentation.

Clinical research has also explored combining pigment-focused and thermal delivery. In a preliminary, uncontrolled study of 20 women with Fitzpatrick IV melasma that had responded poorly to picosecond treatment alone, adding microsecond 1064 nm treatment was followed by further improvement in melasma severity.^[9]

Pro 1 Pico brings Picosecond and Long Pulse YAG into one console, supporting assessment-led pigment and selected vascular or thermal protocols. This configuration gives your clinic room to develop a broader service without adding a separate console for each delivery mode.

The clinical studies above used other devices. Their findings explain the research behind delivery choices; they do not validate Pro 1 Pico-specific outcomes. Nanosecond Q-switched treatment in those studies is distinct from Pro 1 Pico’s quasi-nanosecond PicoFusion™ mode. Melasma can recur, and laser treatment forms part of a broader management plan.

Do you want to build skin-quality services alongside tattoo and PMU removal?

Ultra-Short Picosecond supports tattoo, permanent makeup removal and pigment-focused services. PicoFusion™ adds a quasi-nanosecond stacked-pulse mode for skin-quality and collagen-banking protocols. Long Pulse YAG adds longer-duration 1064 nm delivery for vascular, redness and dermal-heating protocols.^[5]

Build your treatment menu around your patients and clinical priorities, with three delivery modes in one platform and manufacturer-direct training to put them to work.

Which handpieces will support your service plans?

Pro 1 Pico pairs its native 1064 nm source with integrated frequency-doubled 532 nm. The 585 nm and 650 nm dye handpieces add wavelength options for selected tattoo pigments.^[5]

PicoMatrix adds fractional delivery for skin-quality, texture and acne-scar protocols. Choose from three named patterns:

See the full handpiece configuration in action and choose the package that supports your services from day one.

Cynosure also offers fractional treatment through Platinum Focus. Its acne-scar and wrinkle indication covers Fitzpatrick I–IV; that range applies to those fractional treatments. Cynosure separately lists flat-lens pigment treatment for I–VI.^[2][4]

Manufacturer-direct training and support

Buy Pro 1 Pico manufacturer-direct from Pro 1 Laser, with clinical training, onboarding and protocol guidance. Your team can learn the platform’s modes and handpieces with support from the people behind the device.

With a 30-million-pulse platform allowance, Pro 1 Pico gives you a stated allowance to include in your ownership planning. Your proposal brings the equipment configuration, training, warranty and service arrangements together, so you can plan your purchase and launch your services with clear ownership terms. Individual optic replacement terms remain separate from the platform allowance.

Put Pro 1 Pico to work for your clinic

Tell us which services you want to add and which patient groups you serve. We will demonstrate the relevant modes and handpieces and prepare a proposal for your clinic.

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This comparison covers PicoSure Pro; original PicoSure and used units may have different configurations. Pro 1 Pico applications and protocols depend on patient selection, settings and market-specific indications.